NONMEM TUTORIAL PART II: ESTIMATION METHODS AND ADVANCED EXAMPLES

NONMEM Tutorial Part II: Estimation Methods and Advanced Examples

In this second tutorial on NONMEM, the examples of typical pharmacokinetic/pharmacodynamic modeling problems that occur in the pharmaceutical field will be presented, which the reader can use as a template for his read more or her own modeling endeavors.Each of the problems presented is challenging in some way, and the logic behind setting up each

read more


The Effect of Distributive, Procedural, and Interactional Justice on Organizational Cynicism Moderated by Hope

Theoretical and empirical evidence suggests that organizational justice impacts organizational cynicism, but the influence of its various dimensions is inconsistent.This inconsistency necessitates the introduction of moderating variables for a more comprehensive understanding.In this context, hope is selected as a moderating variable due to its abi

read more

Leaf-like sepals induced by ectopic expression of a SHORT VEGETATIVE PHASE (SVP)-like MADS-box gene from the basal eudicot Epimedium sagittatum

Epimedium L.(Berberidaceae, Ranales), a perennial traditional Chinese medicinal herb, has become a new popular landscape plant for ground cover and pot culture in many countries based on its excellent ornamental characteristics and, distinctive and diverse floral morphology.However, little is known about the molecular genetics of flower development

read more

Molecular characterization on the fractionation of organic phosphorus induced by iron oxide adsorption using ESI-FT-ICR MS

The interaction between organic phosphorus (OP) and iron oxide significantly influences the phosphorus cycle in the natural environment.In shallow lakes, intense oxidation-reduction fluctuations constantly alter the existing form of iron oxides, but little is known about their impact on the adsorption and fractionation of OP molecules.In this study

read more